Mouse Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 1 (GRIN1) ELISA Kit-Sandwich

Glutamate receptor ionotropic, NMDA 1 is a part of N-methyl-D-aspartate (NMDA) receptors (NMDARs), which function as heterotetrameric, ligand-gated cation channels notable for their high calcium permeability and voltage-dependent block by Mg2+. In mice, the Grin1 gene (also known as NR1) is primarily linked to subunits of NMDA receptors, which are critical for neurotransmission, synaptic plasticity, and brain development. The NR1 subunit, encoded by the Grin1 gene, is an indispensable element of the NMDA receptor, and any loss or malfunction can result in various behavioral and cognitive issues. Grin1 knockout mice (like Grin1Rgsc174/Grin1+) exhibit significant anxiety-like behaviors, such as diminished fear memory and a reduced acoustic startle response. Additionally, these mice display increased locomotor activity in open field tests, although their social behavior appears unaffected.