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Mouse Autophagy Related Protein 12 (ATG12) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Autophagy Related Protein 12 (ATG12) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse ATG12 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Ubiquitin-like protein ATG12 is integral to the formation of autophagy vesicles. It conjugates with ATG5 through a ubiquitin-like system, requiring ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, to function effectively. In mouse models, the absence of ATG12 results in various physiological and pathological outcomes. For instance, ATG12-deficient mice display neurodegenerative alterations, such as neuronal dysfunction and motor impairments, closely linked to the impairment of autophagy. Additionally, the lack of ATG12 leads to reduced tumor cell proliferation, possibly due to decreased mitochondrial biogenesis and disrupted cellular energy metabolism.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.