Mouse Biogenesis of Lysosome-Related Organelles Complex 1 Subunit 1 (BLOC1S1) ELISA Kit-Sandwich

Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC1S1) is a component of the BLOC-1 complex, essential for the normal formation of lysosome-related organelles (LROs), including platelet dense granules and melanosomes. Alongside the AP-3 complex, BLOC-1 is crucial for directing membrane protein cargos into vesicles formed at cell bodies, facilitating their delivery into neurites and nerve terminals. BLOC1S1 is a vital part of the lysosome-associated membrane protein complex (BLOC-1), which plays a significant role in the biogenesis, maintenance of homeostasis, and function of endolysosomes and mitochondria. In the hippocampus of mice, loss of BLOC1S1 results in altered amino acid and phospholipid metabolism, potentially impacting neuronal homeostasis and function. Additionally, BLOC1S1 deficiency is linked to abnormalities in retinal pigment epithelial cells and the development of age-related macular degeneration (AMD).