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Mouse Anti-Rat T-Kininogen 1 (KNT1) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for rat T-kininogen 1. It is purified by protein A and protein G. It can be applied to WB, IHC, ICC and IP assays of rat T-kininogen 1.
Specifications
Target Information
Rat T-kininogen 1 is a 68 kDa acute-phase glycoprotein whose N-terminal cystatin-like domain inhibits cysteine proteases, while its C-terminal sequence releases T-kinin upon kallikrein cleavage, mediating rapid inflammatory vasodilation. A solvent-exposed 14-aa "KVE" loop (aa 218-231) between the two domains folds into a β-hairpin unique among rat kininogens, presenting a conformational epitope preserved after secretion and fixation. Affinity-purified antibodies targeting this loop trace native T-kininogen 1 in hepatic sinusoids, stimulated serum, and renal proximal tubules, delivering crisp cytoplasmic granules and single-band clarity on immunoblots with no cross-reaction to H-kininogen or α-2-thiol proteinase inhibitor.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.