Recombinant Mouse Polyubiquitin-B (Ubb), N-His

Mouse Polyubiquitin-B (Ubb) is a polyubiquitin gene that plays a key role in maintaining intracellular ubiquitin levels. It is expressed in almost all cell types and is crucial for protein degradation, DNA repair, cell cycle regulation, and cell signal transduction. Ubb is highly expressed in germ cells of the testes and is essential for meiotic progression and spermatogenesis. Ubb knockout mice exhibit adult-onset hypothalamic neurodegeneration and infertility in both male and female mice. During postnatal testicular development, increased Ubb expression is required for the upregulation of Piwi protein levels, which are critical for spermatogenesis. Ubb also interacts with various proteins involved in spermatogenesis and piRNA metabolism. Additionally, Ubb is used as a reference gene in experiments to ensure equal protein loading and to study cellular processes and diseases related to ubiquitin dysfunction.