Recombinant Mouse Osteopontin (Spp1), N-His

Mouse Osteopontin (Spp1) is a secreted glycoprotein that plays a crucial role in various biological processes, including bone remodeling, immune response, and tissue repair. It is highly expressed in tissues such as bone, kidney, and liver. Spp1 is involved in the regulation of cell adhesion, migration, and survival, and it interacts with integrins and CD44 to mediate these functions. In mouse models, Spp1 has been implicated in the progression of diseases such as atherosclerosis, where it promotes plaque formation and inflammation. Additionally, Spp1 is involved in the regulation of immune cell infiltration and has been shown to influence the development of fibrosis and cancer. In the context of Alzheimer's disease, Spp1 is secreted by perivascular macrophages and induces microglial phagocytic states, contributing to synaptic loss.