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Recombinant Chicken Mast/stem Cell Growth Factor Receptor Kit (KIT), N-His-GST
Product Overview
BioVenic's Recombinant Chicken Mast/stem Cell Growth Factor Receptor Kit (KIT), N-His-GST is a recombinant protein expressed from E.coli. Its predicted molecular weight is 52.5 kDa. The purity is> 80%.
Specifications
Target Information
Chicken Mast/Stem Cell Growth Factor Receptor Kit (KIT) is a type III cell surface tyrosine kinase receptor that plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. It is expressed primarily on the progenitors of the reproductive, hematopoietic, and melanogenesis systems. KIT acts as a cell-surface receptor for the cytokine KITLG/SCF. When SCF binds to KIT, it can activate several signaling pathways, such as the AKT1 signaling pathway by phosphorylating PIK3R1, and transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. It also promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 20 mM Tris, 150 mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.