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Recombinant Mouse Dihydropyrimidine Dehydrogenase [NADP(+)] (Dpyd), N-His
Product Overview
BioVenic's Recombinant Mouse Dihydropyrimidine Dehydrogenase [NADP(+)] (Dpyd), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 31.6 kDa. The purity is> 95%.
Specifications
Target Information
Mouse Dihydropyrimidine Dehydrogenase [NADP(+)] (Dpyd) is a key enzyme in the catabolism of pyrimidines, specifically uracil and thymine. It catalyzes the first and rate-limiting step in this metabolic pathway, converting these bases into β-alanine and β-aminoisobutyric acid. This enzyme is crucial for maintaining pyrimidine homeostasis and is involved in the metabolism of chemotherapeutic agents like 5-fluorouracil. In mouse models, Dpyd has also been implicated in sleep regulation, with knockout mice showing reduced sleep duration. This suggests a potential role for Dpyd in modulating sleep-wake cycles through its metabolic products, such as β-alanine, which acts as an inhibitory neurotransmitter.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in deionized sterile water to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.