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Rabbit Anti-Rat Farnesoid X Receptor (FXR) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat farnesoid X receptor. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat farnesoid X receptor.
Specifications
Target Information
Rat farnesoid X receptor (FXR, NR1H4) is a 59-kDa nuclear hormone receptor predominantly expressed in rat liver, intestine, kidney, and gallbladder. It is activated by endogenous bile acids (e.g., chenodeoxycholic acid) and exogenous ligands, forming heterodimers with retinoid X receptor (RXR) to regulate target gene transcription. Key functions include maintaining bile acid homeostasis, modulating lipid/glucose metabolism, and regulating intestinal barrier integrity in rats. Dysregulated activity associates with cholestasis, non-alcoholic fatty liver disease, and metabolic syndrome. As a central mediator of bile acid signaling and metabolic balance, rat FXR is a critical target for studying hepatobiliary biology, metabolic disorders, and liver-protective therapeutics.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.