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Rabbit Anti-Mouse Sepiapterin Reductase (SPR) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse sepiapterin reductase. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse sepiapterin reductase.
Specifications
Target Information
Mouse Sepiapterin Reductase (SPR) is a NADPH-dependent enzyme that catalyzes the final step in tetrahydrobiopterin (BH4) synthesis, converting sepiapterin to BH4. It is expressed in brain, liver, and adrenal glands, where it maintains BH4 levels essential for nitric-oxide synthase and aromatic amino-acid hydroxylases. Loss of SPR activity impairs neurotransmitter production and raises oxidative stress. As the key checkpoint of BH4 metabolism, SPR is an important target for studies of neurotransmission, hypertension, and metabolic disorders.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.