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Rabbit Anti-Mouse Growth Differentiation Factor 10 (GDF10) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse growth differentiation factor 10. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse growth differentiation factor 10.
Specifications
Target Information
Mouse growth differentiation factor 10 (GDF-10, BMP-3b) is a 52 kDa disulfide-linked homodimer whose C-terminal TGF-β knot binds BMPR-II and ALK3/6 to restrain osteoblast maturation and promote cartilage homeostasis. A solvent-exposed 16-residue "KVE" loop (aa 102-117) between pre-helix 1 and β2 adopts a β-hairpin unique among mouse GDF/BMP isoforms, presenting a conformational epitope preserved in both pro- and mature forms. Affinity-purified antibodies targeting this loop trace native GDF-10 in calvarial osteocytes, periodontal ligament, and neonatal cartilage, delivering crisp pericellular staining and single-band clarity on immunoblots with no cross-reaction to BMP-2 or GDF-5.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.