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Rabbit Anti-Mouse Lipopolysaccharide Binding Protein (LBP) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse lipopolysaccharide binding protein. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse lipopolysaccharide binding protein.
Specifications
Target Information
Mouse lipopolysaccharide binding protein (LBP) is a 60-kDa acute-phase glycoprotein predominantly synthesized in mouse hepatocytes and secreted into plasma, with secondary expression in intestinal epithelial cells and macrophages. It binds to lipopolysaccharide (LPS) from Gram-negative bacteria, forming high-affinity complexes that enhance LPS recognition by the CD14-TLR4-MD2 receptor complex on immune cells. This interaction amplifies innate immune responses-promoting pro-inflammatory cytokine secretion, phagocyte activation, and pathogen clearance-while also regulating LPS detoxification to prevent excessive inflammation. Inducible by infection, tissue damage, or inflammatory signals, it acts as a key bridge between bacterial detection and immune activation. As a central mediator of LPS-induced immunity, mouse LBP is a critical target for studying sepsis, inflammatory disorders, and host-pathogen interactions.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.