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Rabbit Anti-Mouse Interferon Regulatory Factor 6 (IRF6) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse interferon regulatory factor 6. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse interferon regulatory factor 6.
Specifications
Target Information
Mouse interferon regulatory factor 6 (IRF6) is a 53 kDa DNA-binding factor whose N-terminal IAD clamp grips ISRE motifs while a C-terminal proline-rich tail recruits chromatin remodelers, steering epithelial differentiation. A solvent-exposed 18-aa "SKP" loop (aa 180-197) between β-strands 4 and 5 folds into a β-hairpin unique among murine IRF paralogs, presenting a conformational epitope preserved after phosphorylation and fixation. Affinity-purified antibodies targeting this loop trace native IRF6 in oral epithelium, palatal shelves, and keratinocyte nuclei, delivering crisp punctate staining and single-band clarity on immunoblots with no cross-reaction to IRF3 or IRF7.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.