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Rabbit Anti-Mouse Granulin (GRN) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse granulin. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse granulin.
Specifications
Target Information
Mouse granulin (GRN) is a 68-kDa secreted glycoprotein widely expressed in murine tissues, including brain, immune cells, and epithelial tissues. It undergoes proteolytic processing into bioactive granulin peptides, regulating diverse cellular processes: cell proliferation, tissue repair, inflammatory responses, and lysosomal function. Critical for murine embryonic development, wound healing, and immune homeostasis, it modulates signaling pathways involved in tissue remodeling and anti-microbial defense. Dysregulated expression or processing associates with neurodegenerative diseases (e.g., frontotemporal dementia), fibrosis, and cancer in mouse models. As a multifunctional mediator of tissue physiology and disease, mouse GRN is a key target for studying neurodegenerative pathobiology, inflammatory disorders, and peptide-based therapeutics.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.