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Mouse Troponin I Type 3, Cardiac (TNNI3) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Troponin I Type 3, Cardiac (TNNI3) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse TNNI3 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Troponin I serves as the inhibitory subunit of troponin, the regulatory complex on thin filaments that imparts calcium sensitivity to striated muscle actomyosin ATPase activity. In mice, Tnni3 plays critical roles in both the physiological and pathological functions of the heart. Its deletion or mutation can lead to various cardiomyopathies, such as restrictive and dilated cardiomyopathy. Mice completely lacking the Tnni3 gene typically succumb to cardiac dysfunction within approximately 18 days after birth. Throughout heart development in mice, Tnni3 expression, along with skeletal muscle Tnnt1 and fast skeletal muscle Tnnt2, is crucial for regulating the heart's development and maturation.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Bollen, Ilse A E et al. "Genotype-specific pathogenic effects in human dilated cardiomyopathy." The Journal of physiology vol. 595,14 (2017): 4677-4693.