Mouse Special AT-rich sequence-binding protein 2 (SATB2) ELISA Kit-Sandwich

The DNA-binding protein SATB2 interacts with DNA at nuclear matrix- or scaffold-associated regions, likely recognizing the sugar-phosphate structure of double-stranded DNA. It functions as a transcription factor that regulates nuclear gene expression by binding to matrix attachment regions (MARs) and inducing local chromatin-loop remodeling. SATB2 acts as a docking site for various chromatin remodeling enzymes and recruits corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. In the mouse cerebral cortex and hippocampus, SATB2 is crucial for learning and memory, as it regulates neuronal differentiation and synaptic plasticity. SATB2 deficiency results in decreased synaptic plasticity in the hippocampus, affecting long-term potentiation (LTP) and long-term memory formation, and manifests as reduced anxiety, increased impulsivity, and abnormal social behavior.