Mouse Interleukin 1 Receptor Antagonist (IL1RA) ELISA Kit-Sandwich

Interleukin-1 receptor antagonist protein (IL-1ra) is an anti-inflammatory agent that counteracts the proinflammatory cytokines of the interleukin-1 family, including interleukin-1beta (IL1B) and interleukin-1alpha (IL1A). It safeguards against immune dysregulation and unchecked systemic inflammation triggered by IL-1 in response to various innate stimulatory agents, like pathogens. IL-1ra also exhibits anti-inflammatory and anti-fibrotic properties in lung injury models, capable of reducing inflammation and fibrosis induced by bleomycin (BLM). Research indicates that deficiency in IL-1ra results in heightened susceptibility to infections and inflammation in mice, such as increased vulnerability to lethal endotoxin shock. Conversely, mice that overexpress IL-1ra are protected against endotoxin shock.