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Mouse Glypican 3 (GPC3) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Glypican 3 (GPC3) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse GPC3 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Glypican-3 is a proteoglycan located on the cell surface. It negatively regulates the hedgehog signaling pathway by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins when attached to the cell surface via a GPI-anchor. In mouse melanoma B16-F10, glypican-3 has been identified as one of the tumor antigens. In mice, glypican-3's function is significantly related to its role in human diseases, particularly hepatocellular carcinoma and Simpson-Golabi-Behmel syndrome (SGBS), highlighting its biological importance. By introducing the glypican-3 gene into mouse embryonic stem cells and inducing their differentiation into dendritic cells, a protective immune response against B16-F10 melanoma can be elicited.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.