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Mouse Integrin Beta 6 (ITGb6) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Integrin Beta 6 (ITGb6) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse ITGb6 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Integrin beta-6 serves as a receptor for fibronectin and cytotactin by recognizing the R-G-D sequence in these ligands. Researchers, using a conditional transgenic mouse model, discovered that overexpression of ITGB6 worsened DSS-induced colitis. This was evidenced by heightened inflammatory responses, increased macrophage infiltration, and elevated secretion of pro-inflammatory cytokines. ITGB6 also intensifies intestinal inflammation by activating the Stat1 signaling pathway and enhancing the secretion of integrin ligands. Moreover, ITGB6 is known to promote tumor growth across various cancers. In mouse models of head and neck cancer and pancreatic cancer, ITGB6 facilitates tumor growth by suppressing T cell-mediated anti-tumor immune responses.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.