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Mouse Calprotectin (CALP) ELISA Kit-Sandwich

Cat. No.EK6F879

Product TypeAnimal Immunoassay Kits

Size

Product Overview

BioVenic Mouse Calprotectin (CALP) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse CALP in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.

Specifications

Assay Type ELISA-Sandwich
Specificity The assay kit is specific for Mouse Calprotectin (CALP).
Target Species Mouse
Species Reactivity Mouse
Detection Range 3.13-200 ng/mL
Reproducibility Intra-Assay: CV < 10%; Inter-Assay: CV < 12%
Assay Time Around 90 min
Sample Requirement Serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids.

Target Information

In mice, Calprotectin (S100A8/S100A9) serves various functions, including immune regulation, inflammatory response, antibacterial activity, and effects on multiple diseases. As an endogenous danger signal (DAMP), Calprotectin activates Toll-like receptor 4 (TLR4), thereby amplifying the inflammatory response. Without Calprotectin, mice exhibit a reduced protective response against endotoxin (LPS)-induced sepsis, highlighting its critical role in inflammation. Calprotectin, primarily an antimicrobial protein in neutrophils, inhibits bacterial growth by binding to zinc. In models of Candida albicans infection, the absence of Calprotectin results in diminished infection clearance ability, underscoring its significance in antifungal immunity. Additionally, Calprotectin is vital for immune regulation, promoting the differentiation and function of regulatory T cells (Tregs) to maintain immune tolerance. It also plays a crucial role in the inflammatory response by activating natural killer (NK) cells and enhancing IFN-γ expression.

Target/Biomarker Mouse CALP
Target Synonym CALP

Shipping and Storage

This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

  1. Vogl, Thomas et al. "Pro-inflammatory S100A8 and S100A9 proteins: self-assembly into multifunctional native and amyloid complexes." International journal of molecular sciences vol. 13,3 (2012): 2893-2917.
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