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Mouse Angiotensin1-7 (Ang1-7) ELISA Kit-Sandwich

Cat. No.EK6F882

Product TypeAnimal Immunoassay Kits

Size

Product Overview

BioVenic Mouse Angiotensin1-7 (Ang1-7) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse Ang1-7 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.

Specifications

Assay Type ELISA-Sandwich
Specificity The assay kit is specific for Mouse Angiotensin1-7 (Ang1-7).
Target Species Mouse
Species Reactivity Mouse
Detection Range 31.25-2000 pg/mL
Reproducibility Intra-Assay: CV < 10%; Inter-Assay: CV < 12%
Assay Time Around 90 min
Sample Requirement Serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids.

Target Information

Angiotensin-(1-7) (Ang-(1-7)) is an endogenous peptide generated by the renin-angiotensin system (RAS), which plays significant roles in cardiovascular, renal, and immune regulation. It counteracts the pressor effects of angiotensin II (Ang II) through the activation of Mas receptors, thereby helping to lower blood pressure. In a 5/6 nephrectomy mouse model, Ang-(1-7) significantly enhanced cardiac function and left ventricular remodeling, while reducing myocardial interstitial fibrosis and the expression of inflammatory factors. In aged mice, Ang-(1-7) lowered blood pressure by decreasing cardiac sympathetic nerve activity. Additionally, Ang-(1-7) promotes nitric oxide (NO) production via Mas receptor activation, improving vascular endothelial function and reducing oxidative stress and inflammation. Studies indicate that Ang-(1-7) offers protective effects in myocardial ischemia-reperfusion injury by mitigating myocardial damage through the inhibition of NF-κB and MAPK signaling pathways.

Target/Biomarker Mouse Ang1-7
Target Synonym Angiotensin 1-7

Shipping and Storage

This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

  1. Miller, Amanda J et al. "Angiotensin-(1-7) Improves Integrated Cardiometabolic Function in Aged Mice." International journal of molecular sciences vol. 21,14 5131. 20 Jul. 2020.
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