Recombinant Rabbit Toll-like Receptor 9 (TLR9), N-His

Rabbit Toll-like Receptor 9 (TLR9) is a crucial intracellular pattern recognition receptor that plays a significant role in the immune system by recognizing unmethylated CpG DNA motifs, which are commonly found in bacterial and viral genomes. In rabbits, TLR9 is primarily located in endosomes and endolysosomes, where it helps initiate immune responses against pathogens. TLR9 can also be expressed on the cell surface of certain immune cells, such as neutrophils and B cells, where it contributes to immunomodulation. This surface expression of TLR9 (sTLR9) has been shown to facilitate the activation of endosomal TLR9 (eTLR9)-mediated signaling pathways, enhancing the immune response. Additionally, TLR9 signaling has been implicated in modulating macrophage antifungal effector functions, suggesting its role in combating fungal infections. Overall, TLR9 is essential for maintaining immune homeostasis and responding to various pathogens in rabbits.