Recombinant Mouse Retinol-Binding Protein 4 (Rbp4), N-His

Mouse Retinol-Binding Protein 4 (Rbp4) is a key protein involved in the transport and regulation of retinol (vitamin A) in the bloodstream. It is primarily synthesized in the liver and secreted into the bloodstream, where it binds to transthyretin (TTR) to prevent renal filtration. Rbp4 plays a crucial role in maintaining retinol homeostasis by delivering retinol to target tissues via its receptor, STRA6. In addition to its role in vitamin A metabolism, Rbp4 has been identified as an adipokine that is elevated in states of insulin resistance, obesity, and type 2 diabetes. Elevated levels of Rbp4 have also been associated with chronic inflammatory conditions, metabolic syndrome, and cardiovascular diseases. In mouse models, Rbp4 knockout leads to vitamin A deficiency, highlighting its importance in retinol transport. Rbp4 has also been implicated in non-shivering thermogenesis during cold adaptation, where it enhances retinol delivery to peripheral tissues. Furthermore, Rbp4 has been shown to restrict viral replication, such as in the case of porcine circovirus type 2 (PCV2), by promoting the degradation of viral proteins through selective autophagy.