Recombinant Mouse Pyruvate Dehydrogenase E1 Component Subunit Beta, Mitochondrial (Pdhb)

Mouse Pyruvate Dehydrogenase E1 Component Subunit Beta, Mitochondrial (Pdhb) is a key subunit of the pyruvate dehydrogenase complex (PDH), which catalyzes the conversion of pyruvate to acetyl-CoA, a critical step in cellular energy metabolism. Located in the mitochondria, PDH plays a central role in linking glycolysis to the citric acid cycle. Pdhb is essential for maintaining PDH activity, which is crucial for aerobic respiration and energy production. In mouse models, defects in Pdhb can lead to impaired glucose metabolism and energy deficits, affecting various tissues, including the brain and muscles. Additionally, Pdhb is involved in regulating metabolic pathways and has potential implications in diseases associated with metabolic dysfunction, such as diabetes and neurodegenerative disorders.