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Recombinant Mouse Histone H2A.Z (H2az1), N-His-GST
Product Overview
BioVenic's Recombinant Mouse Histone H2A.Z (H2az1), N-His-GST is a recombinant protein expressed from E.coli. Its predicted molecular weight is 43.4 kDa. The purity is> 95%.
Specifications
Target Information
Mouse Histone H2A.Z (H2az1) is a variant of histone H2A that plays a critical role in chromatin structure and gene expression regulation. It is essential for neuronal survival and is involved in transcription initiation and termination. H2A.Z is predominantly found near transcription start sites and in enhancer regions of active genes. It facilitates DNA accessibility for transcriptional machinery and other chromatin components. In research, H2A.Z is used to study various aspects of gene regulation, chromatin dynamics, and neurological disorders. For example, its depletion in GABAergic neurons or Purkinje cells leads to progressive cerebellar ataxia in mice due to mitochondrial dysfunction. It also has implications in cancer research, as its overexpression is linked to poor prognosis in several types of cancer. Additionally, H2A.Z is used as a marker in studies of memory and neuronal transcription.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.