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Recombinant Mouse Forkhead Box Protein P3 (Foxp3), N-His-GST
Product Overview
BioVenic's Recombinant Mouse Forkhead Box Protein P3 (Foxp3), N-His-GST is a recombinant protein expressed from E.coli. Its predicted molecular weight is 57.6 kDa. The purity is> 95%.
Specifications
Target Information
Mouse Forkhead Box Protein P3 (Foxp3) is a key transcription factor essential for the development and function of regulatory T cells (Tregs). Tregs expressing Foxp3 play a critical role in maintaining immune tolerance and preventing autoimmune diseases by suppressing the activity of effector T cells. Foxp3 regulates the expression of genes involved in Treg function, such as CTLA-4, IL-10, and TGF-β. In mice, Foxp3 deficiency leads to severe autoimmune disorders due to uncontrolled immune responses. Foxp3 is also involved in the regulation of immune responses in cancer, where Tregs can inhibit antitumor immunity. Additionally, Foxp3 is expressed in other cell types, including natural killer cells and some dendritic cells, highlighting its broad role in immune regulation.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 20 mM Tris, 150 mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.