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Recombinant Mouse Collagen Alpha-1(I) Chain (Col1a1), N-His

Cat. No.AP4C195

Product TypeAnimal Proteins

Size

Product Overview

BioVenic's Recombinant Mouse Collagen Alpha-1(I) Chain (Col1a1), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 26.8 kDa. The purity is>90%.

Specifications

Type Recombinant Protein
Species Mouse
Expression System E.coli
Purity >90%
Endotoxin < 1.0 EU/μg
Predicted Molecular Weight 26.8 kDa
Physical State Lyophilized
Formulation PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.

Target Information

Mouse Collagen Alpha-1(I) Chain (Col1a1) is the most abundant protein in the extracellular matrix (ECM) of bone, skin, and tendon. It forms heterotrimeric type I procollagen with the alpha-2 subunit (Col1a2), which undergoes proteolytic processing during fibril formation. In mice, Col1a1 is crucial for the structural integrity of connective tissues. Mice lacking Col1a1 die in utero due to blood vessel rupture. Transgenic mice with reduced Col1a1 levels exhibit defects in mineralized and non-mineralized connective tissues and progressive hearing loss. Col1a1 is also involved in various diseases, including fibrosis and bone diseases such as osteogenesis imperfecta. It interacts with cell receptors like integrinβ, Endo180, and Discoidin Domain Receptors (DDRs), influencing processes like fibrillogenesis and ECM remodeling.

Protein Mouse Collagen Alpha-1(I) Chain (Col1a1)
Protein Synonym Alpha-1 type I collagen
Gene ID 12842
EC No. P11087

Shipping and Storage

This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

User Note

  1. Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.
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