Recombinant Chicken DNA Repair Protein Complementing XP-A Cells Homolog (XPA)

Chicken DNA Repair Protein Complementing XP-A Cells Homolog (XPA) is a crucial component of the nucleotide excision repair (NER) pathway, which is essential for repairing DNA damage caused by UV light and other genotoxic agents. XPA plays a key role in recognizing and binding to DNA lesions, stabilizing the repair complex, and facilitating the recruitment of other repair proteins. In chickens, XPA is highly conserved and shares significant sequence similarity with its human homolog. Mutations in the XPA gene can lead to xeroderma pigmentosum, a disorder characterized by extreme sensitivity to UV-induced DNA damage and a predisposition to skin cancer. XPA is also involved in transcription-coupled repair, ensuring the integrity of actively transcribed genes. In addition to its role in DNA repair, XPA has been implicated in the regulation of cell cycle checkpoints and apoptosis in response to DNA damage.