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Rabbit Anti-Rat Cytochrome P450 7A1 (CYP7A1) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for rat cytochrome P450 7A1. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of rat cytochrome P450 7A1.
Specifications
Target Information
Rat cytochrome P450 7A1 is a 55 kDa hepatic microsomal enzyme whose hydrophobic substrate pocket converts cholesterol to 7α-hydroxycholesterol, initiating bile-acid synthesis. A solvent-exposed 16-residue "QEK" loop (aa 220-235) between helices F and G folds into a β-hairpin unique among rat P450 isoforms, presenting a conformational epitope preserved after fixation. Affinity-purified antibodies targeting this loop trace native CYP7A1 in hepatocyte peroxisomes, portal-zone ER, and bile-duct epithelia, delivering crisp reticular staining and single-band clarity on immunoblots with no cross-reaction to CYP7B1 or CYP8B1.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.