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Rabbit Anti-Mouse Neurofibromin 2 (NF2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse neurofibromin 2. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse neurofibromin 2.
Specifications
Target Information
Mouse neurofibromin 2 (NF2, merlin) is a 68 kDa FERM-domain protein whose N-terminal cloverleaf clamps plasma-membrane PIP2 while an α-helical rod folds back to auto-inhibit downstream Ras-PI3K signaling. A solvent-exposed 18-residue "EKL" loop (aa 185-202) between FERM subdomains B and C presents a β-hairpin unique among ERM/NF isoforms, offering a conformational epitope preserved after paraformaldehyde fixation. Affinity-purified antibodies targeting this loop trace native NF2 in meningeal lining, Schwann-cell paranodes, and renal tubule membranes, delivering crisp cortical rings and single-band clarity on immunoblots with no cross-reaction to ezrin, radixin, or moesin.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.