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Rabbit Anti-Mouse Caspase 2 (CASP2) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse caspase 2. It is purified by protein A. It can be applied to WB, IHC, ICC and IP assays of mouse caspase 2.
Specifications
Target Information
Mouse caspase-2 is a 50 kDa initiator caspase whose N-terminal CARD domain nucleates the PIDDosome, while the p18/p12 catalytic heterodimer cleaves Asp-containing substrates to trigger intrinsic apoptosis. A solvent-exposed 16-aa "KVE" loop (aa 347-362) between the large and small subunits folds into a β-hairpin unique among mouse caspases, presenting a conformational epitope preserved after activation and fixation. Affinity-purified antibodies targeting this loop trace native caspase-2 in oocyte cytoplasm, thymic cortex, and stressed fibroblasts, delivering crisp diffuse and punctate staining with single-band clarity on immunoblots and no cross-reaction to caspase-3 or caspase-9.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.