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Mouse Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (NOX4) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse NOX4 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Nicotinamide Adenine Dinucleotide Phosphate Oxidase 4 (Nox4) is an NADPH oxidase that primarily catalyzes the reduction of oxygen to hydrogen peroxide (H2O2), and to a lesser degree, the reduction of oxygen to superoxide. It may act as an oxygen sensor, regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. In mouse cardiomyocytes, Nox4 generates significant amounts of reactive oxygen species (ROS) and plays a critical role in cardiac remodeling, fibrosis, and apoptosis. Inhibiting Nox4 leads to significant improvements in the mouse heart's response to pressure overload, resulting in reduced cardiac hypertrophy, fibrosis, and interstitial inflammation, as well as enhanced cardiac function.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.