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Mouse Deiodinase, Iodothyronine, Type III (DIO3) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Deiodinase, Iodothyronine, Type III (DIO3) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse DIO3 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Thyroxine 5-deiodinase, or Dio3, is essential for the metabolism of thyroid hormones (TH), specifically in their activation and inactivation through deiodination. It facilitates the transformation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine) into rT3 (3,3',5'-triiodothyronine) and converts T3 (3,5,3'-triiodothyronine) to T2 (3,3'-diiodothyronine) via inner-ring deiodination. Predominantly expressed in neurons within the mouse brain, Dio3 primarily functions to shield the brain from the toxic effects of excess TH. A deficiency in Dio3 results in unusually high TH levels, which can lead to various neurodevelopmental and behavioral issues, including reduced anxiety, increased hyperactivity, atypical social interactions, and inadequate maternal care behaviors.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.