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Mouse Deiodinase, Iodothyronine, Type II (DIO2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Deiodinase, Iodothyronine, Type II (DIO2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse DIO2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Type II iodothyronine deiodinase is essential in thyroid hormone metabolism, particularly in the activation and inactivation of these hormones through deiodination. It catalyzes the conversion of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and rT3 (3,3',5'-triiodothyronine) into T2 (3,3'-diiodothyronine) via outer-ring deiodination (ORD). Dio2 is chiefly responsible for converting T4 to T3, a vital step in sustaining thyroid hormone balance. Mice deficient in Dio2 (D2KO) display thyroid dysfunction, including elevated TSH levels and increased tolerance to T4, while maintaining normal T3 levels. Furthermore, Dio2 facilitates cold-adaptive thermogenesis in brown adipose tissue by regulating energy metabolism through enhanced T3 production.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.