Mouse Cyclic ADP Ribose Hydrolase (cADPRH) ELISA Kit-Sandwich

Cyclic ADP-ribose hydrolase 1, also known as CD38, synthesizes the second messengers cyclic ADP-ribose (cADPR) and nicotinate-adenine dinucleotide phosphate (NAADP). cADPR acts as a second messenger for glucose-induced insulin secretion, while NAADP serves as a Ca2+ mobilizer. CD38 is a multifunctional transmembrane protease that has varied physiological and pathological roles in mice. In the immune system, CD38 regulates immune responses through its enzymatic activity and functions as an auxiliary molecule for the B cell receptor. For instance, mice lacking CD38 exhibit significant immune deficiencies, including weakened responses to T cell-dependent antigenic proteins and heightened responses to certain polysaccharide antigens. CD38 is highly expressed in the mouse brain, and its deficiency can mitigate neurodegenerative damage and neuroinflammation, potentially due to increased NAD+ levels, which are typically associated with anti-inflammatory and protective effects.