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Mouse Collagen Type II (COL2) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Collagen Type II (COL2) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse COL2 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Collagen type II is a crucial antigen in the CIA (collagen-induced arthritis) model. Arthritis can be triggered by injecting isotypic or heterotypic collagen type II into immunized mice, making this model a widely used tool for studying the immune mechanisms of rheumatoid arthritis. For example, DBA/1 mice develop typical arthritis after collagen type II injection, characterized by synovial hyperplasia, inflammation, and destruction of cartilage and bone. The occurrence of CIA is closely linked to the synergistic effects of humoral and cellular immunity, particularly the role of anti-collagen type II antibodies and T cell-mediated immune responses. Beyond its role as an antigen in the CIA model, collagen type II is also involved in bone and cartilage development and the maintenance of ocular tissue health in mice.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.