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Surgically-induced Animal Model Development Service
Introduction
With specific experience and expertise in animal models and experimental services, BioVenic offers comprehensive and high-quality services for your preclinical research needs. We have a wealth of experience with various classes of meldeed laboratory animals including, but not limited to rodent, rabbit, canine and feline which enables us to deliver complex surgically created animal disease models. We provide our services in many different avenues of study including: cardiovascular disease, metabolic disorder, orthopedic disease, cancer, etc.; our goal is to deliver high-quality animal models and accurate in vivo data through our dedicated team of individuals.
BioVenic Surgically-induced Animal Model Development Services
BioVenic provides an extensive range of services that can be tailored to meet your needs, helping your project get underway with maximum accuracy and reproducibility.
Custom Surgical Animal Model Construction
BioVenic has extensive experience in developing a wide range of established animal models, including Myocardial Ischemia-LCA Ligation, Osteoarthritis-DMM/ACLT, and Hepatic Fibrosis-BDL, to name a few. However, understanding the requirements of cutting-edge research, we also offer custom model construction services, with our experienced team of surgeons and veterinarians capable of developing novel or highly specialized animal models according to your specific requirements, parameters, or even complex disease states.
Surgical Animal Model Validation and Characterization
In order for preclinical research to be successful, accurate and well-characterized animal models are required. BioVenic provides complete validation of the animal model through the characterization of certain defined pathological and physiological endpoints of the disease under investigation. Quantification of tissue damage, function, or certain biological markers using gold-standard techniques is performed to ensure that the model closely reflects the human disease condition and is ready for testing of therapeutics.
Non-GLP Exploratory Drug Development and Efficacy Assessment
Utilize BioVenic's animal models for preclinical drug development, efficacy assessment, and exploratory drug research. BioVenic conducts in vivo drug efficacy tests by monitoring physiological and biochemical changes in animals prior to and after drug administration or therapeutic intervention. Some of the preclinical drug development and efficacy assessment methodologies include:
- Biochemical Endpoint Assessment: Quantification of cytokines, enzymes, and metabolites using very sensitive methods such as ELISA, RT-PCR, Western Blot, and clinical chemistry analyzers.
- Pharmacodynamic (PD) Studies: Monitoring changes in heart rate, blood pressure, blood glucose, or other relevant physiological parameters.
Surgical Animal Model Sampling and Pathology Studies
BioVenic provides meticulous sample collection and comprehensive downstream analysis to fully characterize the therapeutic impact. Services include:
- Tissue Sampling: Precise and consistent collection of target organs and tissues.
- Histopathology: Routine H&E staining, special stains, and Immunohistochemistry (IHC) for structural and molecular analysis.
- Other Investigative Modalities: Imaging studies (e.g., X-ray, Ultrasound), Behavioral studies, and Cytology are available upon request to provide a complete picture of the therapeutic effect.
Explore BioVenic's investigative modalities:
- Animal Behavioral Analysis
- Animal Histopathology Service
- Preclinical Animal Pharmacodynamics (PD) Study
- Preclinical Animal Pharmacokinetics (PK) Study
- Animal Cell Biology Service
- Animal lmaging Service
We also provide other animal model development services, including:
- Genome-edited Animal Model Development
- Chemically-induced Animal Model Development
- Diet-induced Animal Model Development
- Biologically-induced Animal Model Development
Development Workflow for a Surgically-Induced Animal Model
Fig. 1 BioVenic Surgically-induced Animal Model Development Workflow (BioVenic AI)
Common Applications of Surgically-induced Animal Models
As an experienced CRO provider specializing in animal experimentation, BioVenic offers a comprehensive range of custom surgical models for both basic research and preclinical studies. Common applications of surgically-induced animal models are shown as follows.
Table. 1 Common Surgically-induced Animal Models
| Model Type | Induction Method | Applicable Animal Species |
|---|---|---|
| Cardiovascular Diseases (CVD) | ||
| Myocardial Ischemia (MI) / Myocardial Infarction (AMI) Model | Coronary Artery Ligation (LCA Ligation) | Rat, Mouse |
| Pressure Overload-Induced Heart Failure Model | Abdominal Aorta Constriction (AAC) | Rat |
| Hypertension Model | Renal Artery Stenosis | Rat |
| Metabolic Diseases | ||
| Type 1/2 Diabetes Mellitus (DM) Model | Pancreatectomy (Partial or Total) | Rat, Mouse |
| Type 2 Diabetes Mellitus (DM) Model | Partial Gastrectomy (Sleeve Gastrectomy) / Gastric Bypass Surgery | Mouse |
| Hepatopathy & Fibrosis | ||
| Hepatic Fibrosis Model | Bile Duct Ligation (BDL) | Rat, Mouse |
| Liver Regeneration Model | Partial Hepatectomy | Mouse |
| Orthopedic & Bone Diseases | ||
| Osteoarthritis (OA) Model | Destabilization of the Medial Meniscus (DMM) Surgery | Rat, Mouse |
| Anterior Cruciate Ligament Transection (ACLT) / Meniscus Transection | Rat, Mouse | |
| Hulth Method (Tibial Plateau Osteotomy) | Rat | |
| Intra-articular injection of Mono-iodoacetate (MIA) | Mouse | |
| Osteoporosis (OP) Model | Ovariectomy (OVX) / Orchiectomy (Castration) | Rat, Mouse |
| Rotator Cuff Injury Model | Surgically Induced Supraspinatus Tendon Injury | Rat |
| Closed Fracture Model | Intramedullary Kirschner Wire Fixation followed by Calibrated Pressure | Rat |
| Bone Defect Model | Surgically Induced Femoral or Skull Defect | Rat |
| Mandibular Defect Model | Surgically Induced Defect | Rat |
| Neurological & Pain Studies | ||
| Sciatica/Low Back Pain Model | Partial Ligation of the Sciatic Nerve | Mouse |
| Spinal Cord Injury (SCI) Model | Surgically Induced SCI | Rat, Mouse |
| Brain Implantation Model | Stereotactic Implantation | Mouse |
| Other Advanced Models | ||
| Subcutaneous Tumor Xenograft Model | Subcutaneous Cell Injection | Rat, Mouse |
| Orthotopic Tumor Model | In situ Implantation | Rat, Mouse |
| Periodontitis Model | Silk Ligature around Teeth | Rat |
| Hypophysectomy Model | Surgical Removal of Pituitary Gland | Rat |
| Ligament Injury Model | Paratenon Injury | Rat, Rabbit |
Advantages of BioVenic Surgically-induced Animal Model Development Service
Comprehensive Model Library
BioVenic has the experience and resources available to build a variety of surgically-induced models of disease, ensuring that we can address your research needs.
Commitment to Animal Welfare
We strictly follow the highest standards of animal welfare. BioVenic's expert methods and tailored approaches are designed to minimize unnecessary suffering and stress, in accordance with ethical regulatory guidelines.
Timely Project Updates
A dedicated project manager serves as your single point of contact, ensuring that you receive timely and transparent progress reports at every stage of your study.
Case Study: Unraveling the Anti-Osteoporosis Effects of Resistance Exercise in OVX Rats
The Ovariectomized (OVX) rat model is considered the "gold standard" in biomedical research for simulating postmenopausal osteoporosis and estrogen deficiency in humans. Scientists used a Surgical Ovariectomy (OVX) model to induce postmenopausal osteoporosis in Sprague-Dawley rats. They performed a standardized bilateral laparotomy to remove the ovaries, which eliminated the body's natural estrogen. The model's success was rigorously validated through uterine weight measurements (confirming post-op atrophy), Micro-CT morphometry (showing significant decreases in BV/TV and Tb.N), and transcriptomic profiling to identify differentially expressed genes (DEGs) in bone tissue. As a specialized CRO, we offer a comprehensive "Surgery-to-Bioinformatics" workflow, providing expert OVX surgical modeling, standardized bone micro-architecture validation, and high-throughput RNA-seq analysis to help you elucidate the molecular mechanisms of your anti-osteoporosis candidates.
Fig. 2 Micro-CT 2D Images in the Trabecular Architecture of Distal Femurs1
FAQs
Do you supply live animal models for purchase?
No. We currently do not offer the sale of live animals. BioVenic's service focuses exclusively on providing end-to-end technical services, including model construction, validation, in vivo experimentation, and data analysis.
Can you do a combination of two different surgical procedures on the same animal?
Yes. We often perform complex and combined surgical procedures to better reflect the complexity of human disease, such as combining a metabolic model with a cardiovascular model, pending ethical review and feasibility.
What is the typical turnaround time for a custom model development project?
This depends on the complexity of the surgery, the time needed for model validation, and the following study duration.
Contact Us
With our expertise in surgical procedures and integrated animal experimental research platform, BioVenic can assist in the development of a variety of animal surgical models, thereby facilitating preclinical non-GLP drug development and overall experimentation. Ready to advance your preclinical research with expertly developed and validated surgical animal models? Partner with BioVenic for reliable models, precise data, and unparalleled service transparency. Contact us today to discuss your project and request a custom quotation.
References
- Wang, Qing, et al. "Anti-osteoporosis mechanism of resistance exercise in ovariectomized rats based on transcriptome analysis: a pilot study." Frontiers in Endocrinology 14 (2023): 1162415. https://doi.org/10.3389/fendo.2023.1162415. Distributed under Open Access license CC BY 4.0. Figure 3(A) was extracted. The original title was changed to "Macro- and Micro-scopic Assessment of DSS-induced Colitis Animal Colon."