Recombinant Mouse Proliferating Cell Nuclear Antigen (Pcna), N-His

Mouse Proliferating Cell Nuclear Antigen (PCNA) is a crucial protein involved in DNA replication and cell cycle regulation. It acts as a sliding clamp for DNA polymerase δ and ε, enhancing their processivity during DNA synthesis. PCNA is essential for coordinating leading- and lagging-strand synthesis at the replication fork and facilitates DNA repair through various pathways like mismatch repair, base excision repair, and nucleotide excision repair. It also interacts with cyclin A-Cdk2 complex, influencing cell cycle progression from G1 to S phase. In research, PCNA serves as a marker for cell proliferation and is used to study cancer progression, DNA replication mechanisms, and the pathophysiology of diseases related to DNA damage. PCNA knockout in mice leads to developmental defects and highlights its importance in maintaining genomic integrity.