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Recombinant Mouse Dual Specificity Protein Phosphatase 1 (Dusp1), N-His-GST
Product Overview
BioVenic's Recombinant Mouse Dual Specificity Protein Phosphatase 1 (Dusp1), N-His-GST is a recombinant protein expressed from E.coli. Its predicted molecular weight is 51.2 kDa. The purity is> 80%.
Specifications
Target Information
Mouse Dual Specificity Protein Phosphatase 1 (Dusp1), also known as MKP1, is a key enzyme that dephosphorylates both serine/threonine and tyrosine residues. It negatively regulates the MAPK signaling pathway, including ERK, p38, and JNK, which are crucial for cell proliferation, differentiation, and apoptosis. Dusp1 plays a protective role in acute kidney injury by maintaining mitochondrial function and preventing DNA damage. In cancer, Dusp1 expression is linked to drug resistance and tumor progression. Additionally, Dusp1 regulates inflammation and fibrosis in various tissues, including the kidneys. Its broad expression across tissues like the heart and lungs highlights its importance in maintaining cellular homeostasis.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.