Recombinant Mouse Alcohol Dehydrogenase 1 (Adh1), N-His

Mouse Alcohol Dehydrogenase 1 (Adh1) is a key enzyme involved in the metabolism of ethanol and fatty acids. It is primarily expressed in the liver and plays a central role in detoxifying alcohol and other xenobiotics. Adh1 catalyzes the oxidation of ethanol to acetaldehyde, a critical step in alcohol metabolism. It also participates in the oxidation of fatty acids and the synthesis of ketone bodies. Adh1 is associated with various diseases, including alcohol-induced liver disease and fatty liver disease. In mouse models, Adh1 deficiency leads to increased oxidative stress and liver injury, highlighting its role in protecting against alcohol-related toxicity. Additionally, Adh1 has been implicated in cancer progression and is being explored as a therapeutic target in diseases linked to metabolic disorders and alcohol metabolism.