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Recombinant Mouse BH3-Interacting Domain Death Agonist (Bid), N-His
Product Overview
BioVenic's Recombinant Mouse BH3-Interacting Domain Death Agonist (Bid), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 25.8 kDa. The purity is> 97%.
Specifications
Target Information
Mouse BH3-Interacting Domain Death Agonist (Bid) is a pro-apoptotic member of the Bcl-2 family, crucial for death receptor-mediated apoptosis. It is activated by caspase-8 cleavage, leading to the formation of truncated Bid (tBid), which translocates to mitochondria and facilitates cytochrome c release, driving apoptosis. Bid also interacts with Bax and Bak to promote mitochondrial outer membrane permeabilization (MOMP) and amplify apoptotic signals. Additionally, Bid plays roles in non-apoptotic processes, such as regulating mitochondrial cristae structure and function, and has been implicated in diseases like neurodegeneration and cancer. It is a potential therapeutic target due to its dual roles in apoptosis and cellular homeostasis.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.