Recombinant Mouse Creatine Kinase B-Type (Ckb), N-His

Mouse Creatine Kinase B-Type (Ckb) is a crucial enzyme involved in energy metabolism, particularly in muscle and brain tissues. It catalyzes the reversible transfer of a phosphate group from phosphocreatine to ADP, generating ATP. This process is essential for maintaining high-energy demand in tissues like skeletal muscle and the brain. In mouse models, Ckb is expressed in various tissues, including muscle, brain, and brown adipose tissue, where it plays a role in thermogenesis and glucose homeostasis. For example, in thermogenic fat, Ckb controls futile creatine cycling, which is critical for heat production and energy balance. Additionally, Ckb interacts with proteins involved in actin polymerization and intracellular trafficking, suggesting its involvement in muscle cell fusion and myogenesis.