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Recombinant Mouse 3-Phosphoinositide-Dependent Protein Kinase 1 (Pdpk1), N-His
Product Overview
BioVenic's Recombinant Mouse 3-Phosphoinositide-Dependent Protein Kinase 1 (Pdpk1), N-His is a recombinant protein expressed from E.coli. Its predicted molecular weight is 33.1 kDa. The purity is> 97%.
Specifications
Target Information
Mouse 3-Phosphoinositide-Dependent Protein Kinase 1 (Pdpk1) is a key serine/threonine kinase that plays a central role in the PI3K-Akt signaling pathway. It activates a range of downstream kinases, including Akt, S6K, and SGK, which are crucial for cell survival, growth, and metabolism. In mouse models, Pdpk1 is essential for embryonic development, with null mutants showing severe developmental defects and embryonic lethality. Pdpk1 also regulates cell size independently of cell number or proliferation. Additionally, Pdpk1 is involved in immune cell development and function, and its deletion can lead to cardiac malformations and heart defects. These functions highlight Pdpk1's importance in both developmental and physiological processes.
Shipping and Storage
This product is shipped with ice packs. Lyophilized protein can be stored at -80°C for 1 year. After reconstitution, the protein solution can be stored at 2-8°C for 2-7 days.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
User Note
- Always centrifuge tubes before opening. Avoid mixing by vortexing or pipetting. Reconstitute in 10 mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Aliquot the reconstituted solution to minimize freeze-thaw cycles.