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Rabbit Anti-Mouse Bruton'S Tyrosine Kinase (Btk) Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for mouse bruton's tyrosine kinase. It is purified by protein A/G. It can be applied to WB, IHC, ICC and IP assays of mouse bruton's tyrosine kinase.
Specifications
Target Information
Mouse Bruton's tyrosine kinase (BTK) is a 76 kDa cytoplasmic kinase whose N-terminal PH-TH module, SH3-SH2 cassette, and C-terminal kinase lobe form a clamp that phosphorylates PLCγ2 and other B-cell signaling substrates after membrane recruitment. A solvent-exposed 16-aa "KVE" loop (aa 340-355) between the SH2 and kinase domains folds into a β-hairpin unique among mouse Tec kinases, presenting a conformational epitope preserved after autophosphorylation and fixation. Affinity-purified antibodies targeting this loop trace native BTK in splenic B-cell follicles, bone-marrow pre-B cells, and peritoneal macrophages, delivering crisp cytoplasmic puncta and single-band clarity on immunoblots with no cross-reaction to Tec or Itk.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.