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Mouse Serine Peptidase Inhibitor Kazal Type 5 (SPINK5) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Serine Peptidase Inhibitor Kazal Type 5 (SPINK5) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse SPINK5 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
SPINK5 encodes the protease inhibitor LEKTI, primarily responsible for inhibiting serine proteases in the epidermis, such as KLK5 and KLK7, to maintain skin barrier integrity. LEKTI binds to serine proteases, preventing their overactivation and thereby avoiding excessive keratinocyte shedding and damage to the skin barrier. In mice, the SPINK5 gene plays a crucial role in skin barrier function, keratinocyte differentiation, and protease activity regulation. These roles have been confirmed in various disease models, particularly in genetic conditions associated with Netherton syndrome (NS).
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Furio, Laetitia et al. "KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome." PLoS genetics vol. 11,9 e1005389. 21 Sep. 2015.