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Mouse Mothers Against Decapentaplegic Homolog 3 (Smad3) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Mothers Against Decapentaplegic Homolog 3 (Smad3) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse Smad3 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Smad3 is a receptor-regulated SMAD (R-SMAD) that functions as an intracellular signal transducer and transcriptional modulator, activated by TGF-beta and activin type 1 receptor kinases. It binds to the TRE element in the promoter regions of numerous TGF-beta-regulated genes, and upon forming a SMAD3/SMAD4 complex, it activates transcription. Additionally, it can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Smad3 serves as a critical effector in the TGF-β signaling pathway, playing a role in regulating T cell and immune cell functions. Mice lacking Smad3 exhibit immune function defects, including thymic involution, lymphadenopathy, and bacterial abscess formation in mucosal areas.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.