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Mouse Claudin-14 (CLDN14) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Claudin-14 (CLDN14) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse CLDN14 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Claudin-14 is crucial for the tight junction-specific sealing of intercellular spaces, achieved through calcium-independent cell-adhesion activity. In mice, Claudin-14 (CLDN14) is predominantly found in the thick ascending limb (TAL) of the renal tubule, particularly within the cortex and upper medulla regions. It influences calcium ion (Ca²⁺) reabsorption by forming heterotrimers with Claudin-16 and Claudin-19, acting as a negative regulator of cation channels. Normally, Claudin-14 expression is suppressed by two microRNAs (miR-9 and miR-374), which target its 3' untranslated region (3'UTR) to promote mRNA degradation and inhibit translation.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.