Mouse Activating Molecule in BECN1-Regulated Autophagy Protein 1 (AMBRA1) ELISA Kit-Sandwich

The Activating molecule in BECN1-regulated autophagy protein 1 (Ambra1) serves as a substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex involved in cell cycle regulation and autophagy. Ambra1 is a key activator and regulator of the autophagy process governed by Beclin-1. During mouse embryonic development, Ambra1 is expressed in the neurocortex, playing an essential role in neuronal differentiation, morphological remodeling, and cytoskeletal reorganization. Research has shown that Ambra1+/- female mice display behaviors akin to autism spectrum disorder (ASD), such as social communication difficulties, repetitive stereotyped behaviors, and impaired cognitive flexibility. These behaviors are linked to a reduction in inhibitory neurons in the hippocampus, decreased synaptic plasticity, and imbalanced neural network activity.