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Mouse Early Growth Response Protein 1 (EGR1) ELISA Kit-Sandwich
Product Overview
BioVenic Mouse Early Growth Response Protein 1 (EGR1) ELISA Kit-Sandwich is designed for the quantitative determination of Mouse EGR1 in serum, plasma, tissue homogenate, cell culture supernatant, cell lysate, and other biological fluids using a Sandwich ELISA method. For research use only.
Specifications
Target Information
Early Growth Response Protein 1 (Egr-1) is a transcriptional regulator that identifies and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (EGR-site) located in the promoter region of target genes. It can bind to double-stranded DNA regardless of the cytosine methylation status. In mice, Egr-1 is involved in various functions such as the inflammatory response, angiogenesis, memory and learning, and pancreatitis. It plays a pivotal biological role by influencing the expression of downstream genes. Research on age-related cognitive decline has highlighted the strong association between Egr-1 and cognitive abilities. For instance, in the SAMP10 mouse model, there is a positive correlation between Egr-1 expression levels and memory capabilities, indicating that Egr-1 might enhance cognitive function by regulating neuronal synaptic plasticity.
Shipping and Storage
This product is shipped with gel ice packs. It is recommended to store at 2-8 °C (Up to 6 months).
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Unno, Keiko et al. "Green Tea Catechins Trigger Immediate-Early Genes in the Hippocampus and Prevent Cognitive Decline and Lifespan Shortening." Molecules (Basel, Switzerland) vol. 25,7 1484. 25 Mar. 2020.