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Feed Fumonisins Solution
BioVenic provides feed fumonisin (mycotoxin) analysis and mitigation services for the detection and detoxification of fumonisins in animal feed, supporting feed mycotoxin safety assessment, feed additive and bioprocess development, and animal nutrition research. Our platform covers fumonisins (FB1, FB2, FB3, and A/C/P analogues) via ELISA, lateral flow assays, and HPLC with fluorescence detection, along with feed additive (esterase, clay adsorbents) development and biological detoxification through microbial fermentation and enzymatic degradation. We support fumonisin-related animal research with in vitro and in vivo models and multi-omics (microbiome, metabolome, proteome) analyses to evaluate intervention efficacy and safeguard animal health.
Fig. 1 Chemical structures of fumonisins B1, B2, B3, and B41,2
Origin and Types of Fumonisins
Fumonisins are chiefly produced by Fusarium verticillioides (previously known as F. moniliforme), F. proliferatum, F. oxysporum, F. globosum, various other Fusarium species, and Alternaria alternata f. sp. lycopersici. The most prevalent form is FB1, while related metabolites like fumonisin B2 (FB2) and fumonisin B3 (FB3) are typically found in lower quantities. Additionally, the A, C, and P series encompass other recognized fumonisin analogues.
Fumonisin Hazards in Animals
Numerous animal ailments and cancerous conditions, such as leukoencephalomalacia (ELEM), porcine pulmonary edema (PPE), liver toxicity, hepatocarcinomas, kidney damage, and immunosuppression, are commonly linked to fumonisins. Among the fumonisin variants, FB1 stands out as the primary form and principal toxin. The provided table illustrates the varying impacts of fumonisins on distinct animal species.
Table. 1 Impact of fumonisins on animals
| Animal Types | Effects |
|---|---|
| Pigs |
|
| Horses |
|
| Chickens |
|
| Fish |
|
Feed Fumonisins Solutions
Our feed fumonisin solutions facilitate fumonisin analysis, aiding in the development of feed additives and biological processes to mitigate the harmful impacts of fumonisins in animal feed. Additionally, our services encompass efficacy studies and action mode evaluations utilizing diverse animal models.
- Fumonisin Analysis Solutions
Our Animal Feed Mycotoxin Analysis services offer feed fumonisin detection services for various sample types and applications. Commonly employed detection methods include enzyme-linked immunosorbent assay (ELISA), lateral flow rapid assay, and high-performance liquid chromatography (HPLC) with fluorescence detection. These assays effectively identify fumonisin contamination in feeds and support researchers in devising strategies for fumonisin detoxification.
- Feed Additive Development for Fumonisins
To counteract the negative impacts of fumonisins in animal feed, studies have investigated the effects of different feed additives on animal health in fumonisin-exposed animals. Our solution for Feed Additive Development for Fumonisins assesses the efficacy of various types of feed additives and aids in the formulation of highly potent additives to alleviate the harmful effects of fumonisins in animals. Some additives that show promise in reducing fumonisin-related adverse effects include:
- Fumonisin esterase,
- Bentonite and enzymatically hydrolyzed yeast,
- Nanosilicate clay platelets,
- Boron-fructose.
- Development of Biological Detoxification for Fumonisins in Animal Feed
Biological detoxification methods, such as fermentation and enzymatic processes, provide cost-effective and efficient ways to detoxify fumonisins in animal feed. By examining how microorganisms and enzymes interact with fumonisin-contaminated feed, we assist in identifying and cultivating strains and enzymes that can mitigate the detrimental impacts of fumonisins in animal feed. Some of the beneficial biological detoxifying microorganisms and enzymes include:
-
Microorganisms:
Lactobacillus plantarum MYS6
L. rhamnosus strain GG
L. paracasei BEJ01
L. pentosus X8
Pseudomonas sp. -
Enzymes:
Carboxylesterase FumD
Peroxidase
- Animal Study Solutions for Fumonisins
Through in vitro digestion models, the bioaccessibility of fumonisins in different feed varieties can be assessed. In vivo animal models can then be utilized to explore potential methods for detoxifying animal feed contaminated with fumonisins. At BioVenic, we offer both in vitro and in vivo animal models, as well as animal nutrition and metabolism analysis and omics solutions in animal nutrition and metabolism, facilitating the development of feed fumonisin solutions tailored to different animal species..
Service Workflow of Feed Fumonisins Solution
Related Research
Investigating the protective effects of feed additives against mycotoxicity, Deng et al. evaluated a combination of bentonite adsorbent and enzymatically hydrolyzed yeast (EHY) in newly weaned pigs subjected to chronic dietary exposure of fumonisin and aflatoxin. Nursery pigs were assigned to control diets, mycotoxin-contaminated diets, or contaminated diets supplemented with 0.2% or 0.4% of the bentonite–EHY composite additive. The study demonstrated that while mycotoxin exposure significantly compromised growth performance by decreasing average daily feed intake and weight gain, dietary supplementation with the composite additive dose-dependently rescued these metrics. Biologically, the addition of bentonite and EHY enhanced mucosal structural integrity—evidenced by an increased jejunal villus height to crypt depth ratio and upregulated claudin-1 tight junction protein expression—while beneficially modulating local immune responses via reduced jejunal IgA levels and controlled tumor necrosis factor-alpha activity. These findings highlight the functional efficacy of combining physical clay binders with bio-active yeast hydrolysates to attenuate intestinal epithelial damage, maintain barrier function, and sustain growth performance in swine exposed to complex multi-mycotoxin challenges.
Fig. 2 Tight junction proteins of jejunum of nursery pigs fed diets with or without mycotoxins, and with or without feed additive.3
Why Choose Us?
Cutting-Edge Analysis Platforms
We offer advanced fumonisins analysis platforms and assay development technologies to cater to a diverse range of assay requirements efficiently.
Comprehensive Animal Models
Our research includes a broad spectrum of in vivo and in vitro studies utilizing animal models that represent the major species affected by fumonisins.
Research Expertise
Leveraging both internal capabilities and external research collaborations, we focus on developing effective detoxification strategies for fumonisins. We also investigate the effects and mechanisms of fumonisins across various animal species.
Case Study
Researchers conducted a comprehensive comparative evaluation of fumonisin detoxification approaches to identify the most effective strategies for mitigating FB1, FB2, and FB3 contamination in animal feed. Seven distinct detoxification methods spanning three mechanism categories—adsorptive additives (fumonisin esterase, bentonite with enzymatically hydrolyzed yeast, nanosilicate clay platelets), microbial biotransformation (Lactobacillus plantarum, L. rhamnosus), and enzymatic degradation (carboxylesterase FumD, peroxidase treatment)—were systematically assessed using standardized in vitro detoxification assays coupled with HPLC-FLD quantification of residual fumonisin levels. The grouped horizontal bar analysis revealed clear mechanistic differentiation: enzymatic methods demonstrated the highest broad-spectrum efficacy, with carboxylesterase FumD achieving 95% FB1 reduction, 90% FB2 reduction, and 85% FB3 reduction—representing the most balanced profile across all three toxin variants. Fumonisin esterase followed closely with 92%, 88%, and 85% reductions respectively. Microbial approaches showed moderate-to-strong activity (65–78% range) with strain-dependent variability, while adsorptive additives provided baseline protection (55–75%) but exhibited relatively lower efficacy against the more polar FB3 subtype.
Fig. 3 Detoxification Efficacy
Frequently Asked Questions
Q1: What types of feed samples can be submitted for fumonisin analysis, and what are the specific sample preparation guidelines?
A: We accept a broad spectrum of complex matrices, including raw grains, processed complete feeds, forage, and grain co-products such as distiller's dried grains with solubles (DDGS). To ensure representative testing, we recommend taking multiple incremental core samples from various batch locations before blending. Dried samples should be ground to pass through a fine sieve and shipped in clean, moisture-proof, leak-proof containers at room temperature. For specialized, high-fat, or heavily processed feed matrices, please consult our technical support team to verify optimal sample preprocessing protocols prior to shipment.
Q2: Which fumonisin analogs do your detection services cover, and what analytical platforms are utilized?
A: Our analytical platform provides robust quantification of major B-series fumonisins, including Fumonisin B1 (FB1), Fumonisin B2 (FB2), and Fumonisin B3 (FB3), as well as total fumonisin content. Depending on your screening or high-throughput research needs, we utilize standardized ELISA kits for rapid quantitative screening, alongside liquid chromatography-tandem mass spectrometry (LC-MS/MS) and HPLC for highly accurate, definitive molecular profiling. If you require targeted testing for specific derivative compounds or customized detection thresholds, please reach out to our technical support team for tailored configuration.
Q3: What are the minimum sample amount requirements and expected turnaround times for routine feed analysis?
A: We typically request a minimum of 100 to 200 grams of homogenized feed sample to accommodate potential duplicate testing, routine extraction procedures, and quality control validation steps. Turnaround times may vary slightly depending on sample matrix complexity, the selected detection platform, or specialized batch requirements. If you are working under strict project deadlines or require expedited emergency processing, please contact our technical support specialists prior to dispatching your samples.
The global prevalence of the mycotoxin fumonisins in maize products has emerged as a significant concern. Fumonisins pose health risks to both humans and animals alike. BioVenic's feed fumonisins solutions offer precise and swift detection methods, aiding in the development of efficient detoxification feed additives and biological processes for animals. If you are interested in accessing our feed fumonisins solutions, kindly contact us with your research requirements. We are committed to providing tailored services that align with your specific needs.
References
- Image retrieved from Figure 3 "Chemical structures of fumonisins B1, B2, B3, and B4." Kostić et al., 2019, used under CC BY 4.0. Without modification.
- Kostić, Aleksandar Ž., et al. "Mycotoxins and mycotoxin producing fungi in pollen." Toxins 11.2 (2019): 64. https://doi.org/10.3390/toxins11020064.
- Deng, Zixiao, et al. "Efficacy of feed additive containing bentonite and enzymatically hydrolyzed yeast on intestinal health and growth of newly weaned pigs under chronic dietary challenges of fumonisin and aflatoxin." Toxins 15.7 (2023): 433. https://doi.org/10.3390/toxins15070433. Used under CC BY 4.0. Without modification.